Cell Surface Hydrophobicity and Adhesion: A Study on Fifty Clinical Isolates of Candida albicans

the effect of antifungal compounds on cell surface hydrophobicity and adhesion of candida albicans to buccal epithelial cells

Cell wall protein mannosylation determines Candida albicans cell surface hydrophobicity.

Cell surface hydrophobicity (CSH) has been shown to be an important factor in the ability of the opportunistic pathogenic yeast Candida albicans to adhere to surfaces. Hydrophobic cells adhere more readily to host tissue, and are more resistant to phagocytic killing, than hydrophilic cells. Consequently, CSH plays an important role in the pathogenicity of C. albicans. Previous work suggested a ...

Cell wall mannan and cell surface hydrophobicity in Candida albicans serotype A and B strains.

Cell surface hydrophobicity contributes to the pathogenesis of the opportunistic fungal pathogen Candida albicans. Previous work demonstrated a correlation between hydrophobicity status and changes in the acid-labile, phosphodiester-linked beta-1,2-oligomannoside components of the N-linked glycans of cell wall mannoprotein. Glycan composition also defines the two major serotypes, A and B, of C....

Cloning and analysis of a Candida albicans gene that affects cell surface hydrophobicity.

The opportunistic pathogenic yeast Candida albicans exhibits growth phase-dependent changes in cell surface hydrophobicity, which has been correlated with adhesion to host tissues. Cell wall proteins that might contribute to the cell surface hydrophobicity phenotype were released by limited glucanase digestion. These proteins were initially characterized by their rates of retention during hydro...

Synergistic activity of econazole-nitrate and chelerythrine against clinical isolates of Candida albicans

The aim of this investigation was to assess the in vitro interaction of two antifungal agents, econazole-nitrate and chelerythrine, against ten fluconazole-resistant clinical isolates and one ATCC type strain 10231 of Candida albicans. The checkerboard microdilution method was performed according to the recommendations of the National Committee for Clinical Laboratory Standards, and the results...